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Initially, some patients might need weekly injections, while others might benefit from monthly maintenance dosages

Inject the medication slowly and at a 90-degree angle to help minimize discomfort

This resistance is mediated by different causes and mechanisms, (that are resumed in Table 1 and excellently summarized in different review articles [78].One of the most obvious and intriguing mechanisms of resistance involves alteration in CD38 expression, a crucial factor in both primary and acquired resistance to anti-CD38 therapies

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To located the site, feel for the keel and inject in area 1/2 inch below the top of the keel bone, 3/4 inch above the bottom, and 1/4 inch distance from either side of the keel bone