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960 Preclinical studies have shown that metformin enhances chemotherapy sensitivity by disrupting the HIF-1/PKM2 pathway, inducing apoptosis, and preventing epithelialmesenchymal transition

In its advanced stages, the bones begin to rub against one another, causing pain, stiffness and reduced mobility

Anti-inflammatory properties

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The expiration date provides a conservative estimate of how long the manufacturer can guarantee the medication maintains its labeled potency

Curcumin, a well-known polyphenol with antioxidant and anti-inflammatory properties (Perrone et al., 2019), also becomes more biologically active after microbiome metabolism (Table 2) (Di Meo et al., 2019), suggesting that a diverse microbiome plays an important role in achieving maximum effects from such compounds