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Yao et al., 2023)

Hood DA, et al

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages

96 The iron from lysosomes appears to be taken up into mitochondria, contributing alongside ROS to the opening of the MPTP and subsequent cell death

Although these formulations offered symptomatic relief, limitations such as poor skin penetration, short shelf life, and variability in preparation led to the development of modern, standardized and nanotechnology-enhanced herbal formulations with improved efficacy and stability [32]