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Some of our patients may benefit from B12 injections due to conditions such as pernicious anemia, where the body struggles to produce enough healthy red blood cells because it cannot absorb B12 from food

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Potential interactions include: Metformin (used for type 2 diabetes) Proton pump inhibitors (PPIs) and H2-receptor antagonists (used for acid reflux) Colchicine (used for gout) Nitrous oxide (anaesthetic gas that can inactivate B12) Chloramphenicol (may reduce the haematological response to B12 therapy) If you take any of these medications long-term, discuss B12 monitoring with your healthcare provider

For instance, CD38 regulates the activity of the nuclear and mitochondrial SIRTUINs [6, 34-35]

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as such, dietary supplementation of choline is necessary