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Issues with high toxicity, life-threatening side-effects, cost, parenteral administration and emergence of resistance are drawbacks common to existing antileishmanial drugs such as sodium stibogluconate, meglumine antimoniate, pentamidine and amphotericin B [4, 8]

Additional information The original online version of this article was revised: The last authors family name has been corrected

Li, Z., Cai, M., Liu, Y

Appl Microbiol Biotechnol 109 , 93 (2025)

Int J Mol Sci 21: 1974, 2020

investigated the impact of skin pretreatment with iodine followed by insulin application which reduced blood glucose levels and increased plasma hormone levels, attributed to inactivating endogenous sulfhydryls like glutathione and gamma-glutamylcysteine, thus safeguarding the dermally administered insulin [73]