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As the condition progresses, continuous nociceptive input from the periphery can lead to central sensitization, which involves changes in spinal cord and brain, where repeated pain input enhances the transmission of pain signals in dorsal horn neurons

doi: 10.1007/s10545-013-9664-5 38

Improve Mood When your B12 is low, you are likely more prone to have a low mood or even symptoms of depression

Goodacre A, Consoli U, Andreeff M

Nitric oxide inhibits the transcription repressor yin-yang 1 binding activity at the silencer region of the fas promoter: a pivotal role for nitric oxide in the up-regulation of fas gene expression in human tumor cells