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Coupled with the observation that NO binding at this haem is weaker than that of Hb or Mb [ K NO is 35 orders of magnitude lower in CBS (Vicente et al ., 2014)], a significant rate of nitrite reduction (Table 1), and an inability to form an oxygenbound ferrous species (thus excluding NOdioxygenase activity), CBS may function as a NiR in vivo

In this state, it's incredibly stable and can last for years
[Google Scholar] 46.Lee Chong T., Ahearn E.L., Cimmino L

This weakens the antitumor immune response and creates a persistent immunosuppressive microenvironment, facilitating immune evasion and the progression of H

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