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Additionally other factors prevail under acute and chronic conditions, as we described before (Thomes et al., 2015) to explain these contrasting results

In addition, Nrf2 deficiency in macrophage promoted pro-inflammatory cytokines production (MCP-1, IL-6, and TNF-) and enhanced oxidized low density lipoprotein (oxLDL) uptake, leading to foam cell formation (Ruotsalainen et al., 2013)

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The primary SELENOP/LRP8-dependent mechanism of Se entering the brain is rather well described

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