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Description
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

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This is vastly more dilute than topical formulations, but isolated cells in culture have direct peptide access without any barrier to penetration

Vitamin B3 (Niacin)
AOD-9604 and BPC-157 are both peptides investigated for tissue healing but work through different mechanisms
Available online: 33.Dorothy Crowfoot HodgkinThe Nobel Prize in Chemistry 1964
