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Papandreou C, Patil S, Dobrosielski DA

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The products generated in this reaction are peroxynitrite (ONOO ) which results from the formation of hydroxyl radical (OH), which is greatly reactive and results in the alteration of cellular functioning and cause dysfunction of endothelial cells, and 3) Massive generation of O 2 may result in proliferation and apoptotic death of epithelial cells (Pacher et al., 2007

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Many adults with CVS have sympathetic nervous system dysregulation.10,25,26 Studies have reported increases in sympathetic tone in patients with CVS, recorded through various tests of autonomic function, such as postural adjustment ratio, heart rate variability, tilt table test, and sudomotor tests.10,2729 The most frequent finding in these reports was an adrenergic anomaly, in addition to coexisting abnormalities of vagal cholinergic function