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Because these genetic variants are fixed at conception and cannot be altered by disease, they sidestep the reverse causation problem that affects observational studies

*Correspondence: Liwan Fu, [email protected] Hu, [email protected] This article was submitted to Clinical Nutrition, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Light movement helps disperse the injection and may prevent soreness.

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For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

Adipose tissue exhibits regional variability in receptor density, blood flow, innervation, and metabolic activity