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[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Pinto-Junior D.C., Silva K.S., Michalani M.L., Yonamine C.Y., Esteves J.V., Fabre N.T., Thieme K., Catanozi S., Okamoto M.M., Seraphim P.M., et al

This study documented in humans the variability of the leak pathway in response to systemic inflammation versus the constancy of the pore pathway, and that very large solutes cannot penetrate the paracellular barrier, even in the presence of inflammation

Administer different peptides as separate injections
The science of medicine saves lives and the art of medicine changes them

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One week after the conditioning procedure, treatment was started and continued daily for two months, when mice were tested for behavioral performance, euthanized and brains collected for neuropathology
