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Notably, the origin and fate of acetyl-CoA are key factors that help distinguish between M1 and M2 ( Figure 1 Figure 2 In a nutshell, pro-inflammatory M1 macrophages are metabolically characterized by a high reliance on aerobic glycolysis and present two key breaks in the TCA cycle, leading to the accumulation of citrate, succinate, and itaconate

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The algorithm used a program called insane 24 to generate model membranes according to membrane dimensions and relative lipid compositions, and solvate them the models here solvated only in water

& Bonomo, M

Evaluation of the tolerability of the substances used Overall, our multimodal therapy was well tolerated