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569,570,571 Based on those trials, nivolumab and pembrolizumab had been approved for adjuvant treatment of patients with unresected stage III melanoma

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Furthermore, lactate, as the main metabolic product of the acidic microenvironment, has concentration-dependent effects: low concentrations (510 mmol) may have anti-inflammatory and anti-apoptotic effects, while high concentrations (15 mmol) promote inflammatory factor expression and cell apoptosis (Schneider et al., 2012)