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Rather than daily use indefinitely, some protocols involve intensive periods at 7% followed by maintenance phases at lower concentrations

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Gao J., Gao X., Li W., Zhu Y., Thompson P.J

[16] This feedback mechanism prevents the accumulation of glucose 6-phosphate in the cytosol when glucose is not required for: ATP production

Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, et al

Also, when supplementing to correct an oral contraceptive-induced vitamin depletion, you may be tempted to take large doses
