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[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Rumbold A., Ota E., Hori H., Miyazaki C., Crowther C.A
Although IGFBPs are synthesized primarily in the liver, many normal and malignant tissues such as lung, breast, and ovarian cancers express IGFBPs [6365]
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GSTZ1-1 deficiency activates NRF2/IGF1R axis in HCC via accumulation of oncometabolite succinylacetone
PMID: 10499368
It works by slowing tyrosinase, the enzyme that triggers melanin production
