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NF-B in biology and targeted therapy: new insights and translational implications

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Metab Brain Dis 24(1):147157

Gut-microbiota-derived components and metabolism (e.g., LPS and palmitate) can induce the capillarization of LSECs to promote NASH, liver fibrosis, and HCC development via the products such as mitogenic factor sphingosine-1-phosphate (S1P) and vascular cell adhesion molecule-1 (VCAM-1) [103, 104]

They may have had a slight bulging of the valve flaps due to other conditions, such as dehydration or a small heart

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