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10.1038/s41422-020-00441-1

Although penicillin G remains the first-line therapy for neurosyphilis, ceftriaxone is frequently used as an alternativeparticularly in patients with penicillin G allergy or logistical constraints

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Note that NADH produced during the glyceraldehyde-3-phosphate dehydrogenase reaction is recycled back to NAD + during the lactate dehydrogenase reaction, permitting continued glycolysis in the presence of only catalytic amounts of NAD +