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In parallel, emerging data suggest that gut microbiota composition and its metabolites (notably short-chain fatty acids) display modest menstrual-phase-related variation and are associated with markers of dyslipidemia and dysbiosis, implying that microbiotahost interactions may further modulate lipid handling across the cycle, particularly in women with obesity or metabolic syndrome [121,126]

35,104,116 On August 22, 2022, Novo Nordisk announced the primary results of the Phase II clinical trial for the dual-action compound CagriSema, which demonstrated effective blood sugar reduction and weight loss

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In contrast, in the liver , NNMTderived 1MNAM can actually stabilize SIRT1, potentially exerting beneficial metabolic effects
