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However, when these conditions remain unresolved, the UPR switches to proapoptotic and inflammatory pathways with persistent accumulation of misfolded proteins promoting cell death (Chen et al., 2023)

doi: 10.3389/fimmu.2016.00378

Increased expression of TfR1 and DMT1 has been observed in the SNpc of PD animal models and PD patients [135], potentially enhancing iron uptake

Endocrine 68:265270 [DOI] [PMC free article] [PubMed] [Google Scholar] Elshimy G, Chippa V, Correa R (2019) "Myxedema." Engels K, Rakov H, Zwanziger D, Hnes GS, Rehders M, Brix K, Khrle J, Mller LC, Fhrer D (2016) Efficacy of protocols for induction of chronic hyperthyroidism in male and female mice

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This provides a swift and efficient way for the cells to absorb all the glutathione they need