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Supplemental ascorbate diminishes DNA damage yet depletes glutathione and increases acute liver failure in a mouse model of hepatic antioxidant system disruption

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By triggering NLRP3 activation in human induced pluripotent stem cells (iPSC)-derived microglia through TLR2 engagement and mitochondrial damage, -synuclein species have been shown to directly contribute to innate immunological activation in PD [56, 57]

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[DOI] [PMC free article] [PubMed] [Google Scholar] [175].Bien M, Longen S, Wagener N, Chwalla I, Herrmann JM, Riemer J, Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione, Mol