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These elevated rates occurred primarily during the rapid dose-escalation phase used in Phase 2 trials

Observations in animal models indicate: Some findings also point toward improved responsiveness of fat cells to metabolic signals

, 591 , 924-933, doi: Fan, D., Lin, X., Zhang, F., Zhong, W., Hu, J., Chen, Y., Cai, Z., Zou, Y., He, X., Chen, X., Lan, P., and Wu, X

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Hypertension and metabolic syndrome together lead to more cases of left ventricular hypertrophy, microalbuminuria, increased intima-media thickness, and hypertensive retinopathy (115)

[DOI] [PubMed] [Google Scholar] 31.Liguori I., Russo G., Curcio F., Bulli G., Aran L., Della-Morte D., Gargiulo G., Testa G., Cacciatore F., Bonaduce D., et al