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This aligns with the broader concept that genetic influences on pharmacodynamics and pharmacokinetics are interdependentwhere gene-driven differences in enzymatic metabolism directly alter drug exposure, influencing receptor interactions, signaling cascades, and ultimately clinical effectiveness (Li et al., 2024

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doi: 10.1016/j.addr.2017.10.009 [DOI] [PubMed] [Google Scholar] 51.Achouri D, Alhanout K, Piccerelle P, Andrieu V

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Here we develop a mass spectrometry (MS)-based approach that leverages genetic diversity to nominate functional relationships between 285 metabolites and 11,868 proteins in living tissues