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The first developed molecule aimed to simultaneously activate glucagon and GLP-1 receptors for the treatment of obesity and glucose intolerance [35], improving body weight and glycemic control in a similar manner to exendin-4, a GLP-1 analogue [116]

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[DOI] [PubMed] [Google Scholar] 208.Kenny PJ

Retatrutide is best understood as a research-stage triple receptor agonist with a complex metabolic design