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Critically, the soluble oligomeric form of -synuclein is now widely recognized as the pathogenic species in PD 45

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By inhibiting this enzyme, A1AT decreases the production of superoxides, contributing to a reduction in the overall ROS burden in tissues and helping to limit oxidative damage ( Furthermore, A1AT binds to metal ions such as copper (Cu) and iron (Fe), which catalyze ROS production via the Haber-Weiss and Fenton reactions

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The four senolytic chloroacetamides (referred to as SCLA1, SCLA2, SCLA3 and SCLA4 herein) selectively killed SK-MEL-103 cells undergoing senescence triggered by etoposide, tozasertib or palbociclib (a CDK4/6 inhibitor) (Fig

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