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The CD4+/CD8+ ratio serves as a key marker of immune system aging, with a shift toward CD8+ dominance often linked to chronic inflammation, reduced pathogen defense, and heightened all-cause mortality risk

Am J Physiol Endocrinol Metab 287 : E405E413 Guo Y et al

141 Some interventional clinical trials on the effects of vitamin B 12 supplementation in combination with other micronutrients and/or medications in cases of COVID-19 are currently being recorded in the International Clinical Trials Registry Platform and ClinicalTrials.gov databases registration numbers NCT04395768 (500 g methylcobalamin orally, daily, for 14 days), NCT04751669 (9.6 mg cyanocobalamin orally, once a day, for 14 days), and NCT04828538 (1 mg daily oral B 12 supplementation for up to 60 days)

This held true for both acute administration and chronic treatment protocols lasting up to 24 weeks

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