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Targeting cellular metabolism to improve cancer therapeutics

doi: 10.17179/excli2020-2487

The longest splicing variant of the SLC22A5 gene codes for an OCTN2 variant called OCTN2VT containing an insertion of 24 amino acids in the first extracellular loop, that seems to be localized in the ER (Figure 2

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All participants gave written informed consent before enrollment and were recruited as non-headache controls (CT) or those with CM based on the International Classification for Headache Disorders, second edition (ICHD-3 beta) criteria (Olesen and Third International Headache Classification Committee of the International Headache, 2011)

Si cette tude a t effectue sur 24 semaines, les effets de la carnitine se feront sentir aprs 6 mois de faon significative