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Without this specific arrangement, glutathione would lose its ability to act as an antioxidant

Overall, pharmacological enhancement of WNT signalling may be considered as a strategy to preserve BBB integrity, but those therapies need to be highly cell-specific to avoid potential side effects

The gap between interesting rodent finding and effective human therapeutic is a graveyard of failed drugs that cost billions of dollars and decades of effort

Although it cannot be discarded that other treatments received by the cancer patients (opiates, neuroleptics) and other confounders, like inadequate nutritional status, may contribute to the problem, preclinical in vitro and in vivo studies do support that chemotherapy causes brain neurotoxicity (Rzeski et al., 2004

Toll-like receptor (TLR4) pathways mediate proinflammatory cytokine and interferon responses [207]

Others are early in research but backed by data that demands attention