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Alterations in dendritic arborization have been noted in Mecp2 mutant mice in cortex and hippocampus previously [38]

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This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)

10.1523/JNEUROSCI.1309-11.2011 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Kessler RC, Bromet EJ