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Phase I clinical studies with continuous-infusion of BSO have shown that GSH can be depleted without undue normal tissue toxicity 55,56

Although there was a slight decrease in adiponectin (APN) levels, the difference did not reach statistical significance (Wang et al

GSH is involved in numerous vital functions such as detoxifying electrophiles, scavenging free radicals, maintaining the thiol status of proteins, providing cysteine, modulating DNA synthesis, microtubular-related processes, nitric oxide homeostasis, the activity of neuromodulators as well as immune functions (reviewed in Lu 2009)

Current understanding of polyphenols to enhance bioavailability for better therapies

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Although the exact function of these transcripts is unknown, it has been shown that they act as anti-apoptotic proteins protecting infected neurons [95-96]