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Acknowledgments We thank all authors for their contributions to the article

Our previous study involving a rat model of OA elucidated that L-glutamine (L-Gln) reduces the expression of nitric oxide synthase, cyclooxygenase-2, and matrix metalloproteinase-13 (MMP13) in chondrocytes through the nuclear factor- B pathway, thereby reducing the degradation of extracellular matrix (i.e., aggregator and type II collagen)

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