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While B12 is water-soluble with no established upper safe limit (according to NHS and EFSA guidance), this does not preclude the possibility of adverse reactions, particularly from injectable forms

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Clin Cancer Res 20:45744583 Lammerts van Bueren J, Jakobs D, Kaldenhoven N, Roza M, Hiddingh S, Meesters J et al (2014) Direct in vitro comparison of daratumumab with surrogate analogs of CD38 antibodies MOR03087, SAR650984 and Ab79