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9A, D), possibly due to the intermediate level of IRE1 expression knockdown by shRNA (Supplementary Fig

However, increased Ki67 expression was found in propagated xenografts

Lysis solution was prepared with Nuclei PURE lysis buffer (NUC-201, Sigma-Aldrich), 1 mM dithiothreitol (D9779, Sigma-Aldrich), and 0.1 % Triton X-100 (NUC-201, Sigma-Aldrich) according to manufacturer protocol, and an RNase inhibitor mix (0.04 U/L SUPERaseIN RNase Inhibitor [AM 2696, Thermo Fisher]

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364,365,366,367,368,369 A recent study shows augmented circulating -hydroxybutyrate levels associated with increased NADH/NAD + ratio and impaired glucose metabolism, 370 while a normalized NADH/NAD + ratio can achieve by constructing LOXCAT-mediated conversion of lactic acid to pyruvate

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database