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This effect on heart rate is an important safety issue that needs special attention in future trials since obese individuals are at increased cardiovascular risk

A deficiency can lead to a type of anemia called megaloblastic anemia, causing fatigue and weakness

doi:10.1371/journal.pone.0213274 Isaksen T, Evensen LH, Johnsen SH, et al
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This is why combining them in a formula is logically sound: each provides something the other doesn't
