bpc-157 tight junction proteins intestinal permeability study Claudin-2 upregulation enhances permeability, immune activation, dysbiosis, and mortality in sepsis Mechanisms regulating intestinal barrier integrity

This trial demonstrated a 30% relative risk reduction (RRR) in the 12-week composite endpoint of disease progression (p=0.0007)

The nausea and appetite suppression it causes follow directly from the locations of those receptors (Wilding et al., NEJM 2021)

Lancet (2020) 395(10223):497506

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

Ethics declarations Competing interests SJW is the founder of Ridgeline Therapeutics, HN is a paid employee of Ridgeline Therapeutics and, since manuscript submission, ADW has also become a paid employee of Ridgeline Therapeutics

Each BAC Water Depot Certificate of Analysis documents the lot number, manufacturing date, identity verification, purity assay result, benzyl alcohol concentration confirmation (target 0.9%), appearance/clarity inspection, pH, and the name of the independent testing laboratory that verified the lot