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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

[DOI] [PMC free article] [PubMed] [Google Scholar] 250.Ihara H., Kakihana Y., Yamakage A., Kai K., Shibata T., Nishida M., Yamada K., Uchida K

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