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Correcting a deficiency can remove one biological contributor to low mood, and some people notice less irritability and a more positive outlook

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Similarly, in aging fibroblasts, lysosomal dysfunction leads to impairment of cell ferritinophagy ability, increasing cell resistance to ferroptosis (Masaldan et al

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Also, the activation of caspase-9 ultimately activates downstream effector caspases, including caspase-3 and caspase-7, eventually leading to cell death