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Silencing of HKT1;2 alters the Na + /K + ratio, suppresses the response of SOS1 to salt, and increases salt hypersensitivity (Jaime-Prez et al., 2017

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In many cases, profound hypotension develops intraoperatively after 45 to 60 minutes as a result of decreased vascular responsiveness and decreased myocardial contractility and is often refractory to interventions such as fluid or vasopressor therapy.8, 18, 19 Whichever surgical procedure is chosen, it is clear that anesthesia time should be minimized and long-term medical management will be necessary

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Balshaw T, et al
