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Abstract Paclitaxel is a most widely used anticancer drug with low oral bioavailability, thus it is currently administered via intravenous infusion

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In the past decade, a dysregulation of cellular metabolism has come into focus, leading to the identification of cell metabolism alterations in atherosclerotic lesions (Tomas et al., 2018) as well as in different cell types involved in atherogenesis in hyperlipidemic or/and pro-inflammatory context (Tomas et al., 2018)

The red pepper's spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKK

Globally, nearly 250,000 cases occur each year, and without timely intervention, the mortality rate approaches 100% (Iyer et al., 2021)