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Patients with Leber's hereditary optic neuropathy should avoid cyanocobalamin (hydroxocobalamin is preferred in the UK)

Selectivity does not eliminate desensitization

Initial and 12-month BDNF measurements were modeled using generalised estimating equations to examine the association of BDNF to the various predictors while taking into account the dependence of data from the same volunteer

This is particularly relevant for oral administration, which is subject to intrinsic factor saturation and receptor limitations in the ileum (Paul and Brady, 2017

It may affect your movement and sensation, especially in your legs, cause numbness or pins and needles and decrease your sensitivity to touch, vibration or pain