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Since then, several antiangiogenic therapies, mainly targeting VEGF signaling pathway have been developed and approved for the treatment of a variety of tumors (Table 1)

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The availability of SAMe in hepatocytes leads to phosphatidylcholine production 5

Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a

Acknowledgments We acknowledge the support and guidance of Venketaraman Vishwanath