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2017 study linked very high long-term B12 supplementation to lung cancer risk in male smokers, though the finding was not replicated in a 2019 Norwegian cohort study Cystic acne flares and rare cobalt-related allergic reactions are the most documented real-world adverse effects of high-dose B12 Test serum B12, MMA, and homocysteine before adjusting your dose

This condition is rare but has been reported in several breeds, including: Border Collies Beagles Chinese Shar-Peis Giant Schnauzers Australian Shepherds Treatment of cobalamin deficiency When left untreated, cobalamin deficiency can potentially lead to serious health problems

[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Mellin J.R., Koutero M., Dar D., Nahori M.-A., Sorek R., Cossart P

If these occur, patients should be instructed to seek immediate emergency help (see WARNINGS)