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Synthesis and structure-activity analysis of icaritin derivatives as potential tumor growth inhibitors of hepatocellular carcinoma cells

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As a GSTP1 inhibitor, NBDHEX binds to the H site of GSTP1, forcing GSTP1 to be released from JNK protein, thereby inducing subsequent JNK phosphorylation, leading to tumor cell cycle arrest and apoptosis [163]

In vitro studies were performed in direct trials (Fu et al., 2021

doi: 10.3390/ijms24129824, 109