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Gasomediators (NO, CO, and HS) and their role in hemostasis and thrombosis

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These findings, which revealed the systemic imbalance in amino acid metabolic pathways caused by ACE2 deletion, including impaired ammonia clearance, disrupted lipid metabolism and exacerbated redox imbalance, suggest that ACE2, in addition to its role in RAS modulation, regulates amino acid metabolic networks to maintain nitrogen homeostasis and oxidative defenses

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