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Mutations in the BCS1L gene result in the lethal disorder called GRACILE syndrome (GRACILE: G rowth R etardation, A minoacidurina, C holestasis, I ron overload, L actic acidosis, E arly death)

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Comparison with growth hormone secretagogues Peptides like ipamorelin and CJC-1295 increase growth hormone release, which influences tissue regeneration throughout the body

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The treated cells showed markedly reduced lipogenesis