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Along with this damage, there is a reduction in mitophagy, the process of removing damaged mitochondria, leading to accumulation of damaged mitochondria further contributing to systemic inflammation

IFN- produced by these CD4 + and CD8 + T cells also induces hepatic synthesis of C1 esterase inhibitors (C1INH)

Additionally, astrocytes also play an important role in SN echogenicity alterations