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In PD, ROS (OH) from dopamine metabolism deplete NADPH, impairing Trx reductase (TrxR) activity and leaving Trx oxidized [115]

In another study examining the risk of restenosis after stenting, carriers of the Leu allele had lower erythrocyte GPx1 activity than homozygous carriers of the Pro allele, and the Leu allele conferred an increased risk of restenosis (OR, 2,9

In fact, DNA methylation has been described in many studies involving tamoxifen resistance, identifying two main mechanisms of resistance: downregulation of estrogen receptor (ER) expression and abnormal activation of the PI3K/AKT/mTOR (mammalian target of rapamycin) signaling pathway [149]

In ApoE / mice subjected to chronic mild stress, lipid metabolism disorders, increased adipocyte hypertrophy, and reduced PPARG gene expression promote AS, while PPARG exhibits an anti-ferroptosis effect (Mao et al., 2023)

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It has a role in the development and the functioning of immune cells