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This was in contrast to LDL uptake by the LDLR, which is markedly downregulated when cellular cholesterol levels rise (Figure 2)

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Int J Mol Sci 23(5):2894
Fer-1, a commonly used inhibitor of ferroptosis, has been shown to have a significant role in terms of inhibiting ferroptosis (146)

Thus, a dysregulated homeostasis between energy metabolism and antioxidant machinery may have deleterious effects on the maturation, structural and functional integrity of WM [155]
