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De plus, avec la dose orale maximale, les concentrations plasmatiques sont plus faibles que celles obtenues avec la dose sous-cutane maximale (20 mg par voie orale donnent des concentrations plasmatiques denviron 25 nM, tandis que 1 mg en sous-cutan donne environ 45 nM [36] , [37] )

Women of childbearing potential should be advised that semaglutide should be discontinued at least 2 months before a planned pregnancy

When semaglutide is administered, it activates GLP-1 receptors in the brain, specifically the hypothalamus, which helps to suppress hunger and decrease energy intake