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They are distinct molecules with unique origins and mechanisms, which is precisely why their synergistic potential is so compelling to researchers

AMG 181 targets the 4 7 integrin heterodimer, blocking its interaction with mucosal addressin cell adhesion molecule-1 (MAdCAM-1), the principal ligand that mediates 4 7 T cell gut-homing

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The key distinction is that, unlike the SBIR program, the STTR program requires the small business to establish a formal partnership with a nonprofit research institution

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